Abstract
It is necessary to use the anti-coagulants during the extracorporeal circulation such as artificial liver support system, Heparin is the most common anticoagulant, We used gabexate mes ilate (GM: FOY®) with plasma separation for the extracorporeal circulation because of the inhibitor of blood coagulating enzymes, Continuous injection of FOY® in the rate of 100mg/kg/Hr was performed on the arterial line of the plasmaxs. Plasma from 10 of 11 animals were separated without any troubles. The platelet count and white blood cell count fell 37% and 42% of the initial count for 30min. respectively. However, they increased to 100% and 55% of the initial count for 120min. respectively. Pi, Δp, and Transmembrane pressure (TMP) were within normal levels during the extracorporeal circulation. however, delayed activated coagulation time (ACT) was only showed during the extracorporeal circulation. These results suggest that use of FOY® during the extracorporeal circulation for plasma separation was effective on the anti-coagulant actions.
