Abstract
Supernatant of plasma of which globulin was precipitated by mixing with NaCl and glycine in a bag was dialyzed and then used as regenerated plasma of plasmapheresis. This therapy called salt-amino acid-precipitation (SAP) plasmapheresis was applied for 3 rheumatoid arthritis patients and a SLE patient. 2.5 liters of plasma was exchanged once in a week and 5 to 12 times of the therapy was conducted in each case. Sieving coefficient of IgG was 0.28 and that of albumin was 0.74. No albumin was supplemented for more than 2-month SAP plasmapheresis. Reduction rate of immune complex in serum was 54.3±10.74%. A decrease of urinary protein was observed in the SLE patient. Improvement was also seen in two of the three rheumatoid arthritis patients.
