Abstract
In 28 hemodialysis (HD) patients with bleeding complications, minimal dose of gabexate mesilate (GM) for regional anticoagulation was determined in 3 kinds of circuits. Regular circuits were used in 13 patients (group I). Circuits with double chamber arranged in parallel in the venous line were used in another 4 patients (group II). For remaining 11 patients (group III), circuits with exchangeable chamber were used. Infusion dose of GM during HD was 1600mg/H for group I, 800mg/H for group II and III-A and 600mg/H for group III. In all patients studied, HD were performed without any trouble. It was concluded that the dose of GM for regional anticoagulation in HD can be decreased to 800mg/H without any complications.
