Abstract
Bilirubin adsorption capacity of PAT resin was examined, using icteric human serum obtained by plasmapheresis. PAT resin adsorbs markedly direct and indirect bilirubin, and uric acid from the serum. Ca2+, creatinine, and BUN were also adsorbed relatively well. Little change was observed in the levels of serum albumin, globulin, glucose, amino acids, cholesterol, free fatty acid, trigyceride, Na+, K+, and Cl-. The amount of bilirubin adsorbed by PAT correlates positively with the initial bilirubin concentration of the serum. However, no relation was found between the removal rate and the bilirubin levels of the serum. The ability of bilirubin adsorption of PAT deteriorates gradually according to the time courses. A possibility was suggested to apply the PAT resin to clinical use, if the optimal conditions in temperature, flow rate, volume and shape of the column etc. are determined, and an adequate combination with other hemopurification procedures such as plasmapheresis is established.
