Mechanistic Aspects of System's Antithrombogenicity of Assist Device

Abstract

The short to long term antithrombogenic mechanisms of assist device inner-coated with segmented polyurethane were proposed in conjunction with controlled management of thrombog, enic potential especially focucing clinical cases with weaning process. The thrombogenic potential was controlled by bypass flow rate. The bypass flow rate dependency was gradually decreased as implantation period proceeds, which was rationalized by proposed multilayerd passivation mechanism.