Abstract
The changes of blood coagulation and fibrinolysis during extra corporal circulation (ECC) were studied in 20 cases. Fibrinopeptid A, a sensitive and specific factor of blood coagulation activity, did not increased during ECC, but elevated after heparin neutralization with protamine. FDP increased remarkably during ECC. Antithrombin III, α2 plasmin inhibiter, plasminogen and fibrinogen decreased during ECC. These data suggested that blood coagulation was well controled by heparin, but fibrinogenolysis was activated during ECC