FLUCTUATION OF PLATELET COUNT AFTER CARDIOPULMONARY BYPASS

EFFECTS OF INTRAAORTIC BALLOON PUMPING AND VENTRICULAR ASSIST DEVICE

Abstract

Fluctuation of platelet count was studied in 71 cases to determine the normal hematological response to platelet consumption and destruction after cardiopulmonary bypass, and the effects of prolonged mechanical circulatory assist. The platelet count fell to -66% on 2-3 POD, recovered to preoperative level by 7-8 POD, and rebounded to +75% by 14 POD before subsiding to preoperative level around 30 POD. The length of CPB did not alter this response, but IABP and VAD support significantly suppressed platelet recovery until their eventual removal. Perioperative thrombocytopenia was associated with LOS, MOF, DIC, septicemia, malnutrition, deep vein thrombosis and massive blood transfusion.