The effect of Dimethyl Sulfoxiide (DMSO) on the removal of Bence-Jones protein and sieving coefficients for various proteins in plasma exchange on multiple myeloma

Abstract

DMSO was administered in the hope that DMSO will work favourably in removing Bence-Jones protein at plasma exchange (PE) in patient with Bence-Jones type of myeloma. Administering DMSO resulted in a increase in the sieving coefficient (SC) and removal amount of Bence-Jones protein and the filtrated volume increased and rise in TMP was inhibited. SC of other proteins such as β₂-MG, Alb and IgG were changed in the extracoporeal method, This suggests that DMSO will also change the separability for the various molecular proteins. The side effects were not seen in our clinical application of DMSO.