An Investigation on the Stabilization of Membrane Permiability of Hemofilter

-New Design and the Evaluation of Module-header Port

Abstract

To get optimum result in hemofiltration for rather long period, design of the module without stagnation flow especially in the header port of the module is one of the most important points to be developed. Nine types of newly designed header were fabricated and evaluated both in vitro and ex vivo, They were classified into eddy, straight-in, and side-in type. The degree of stagnation (R) was defined for the evaluation of the header design in vitro. According to this indication, eddy type design was better than straight-in or side-in type module. Results of ex vivo experiments using dogs alse showed the superiority of this design from the view point of the thrombus formation.