CLINICAL EVALUATION OF BIOFILTRATION

Abstract

Soft HDF is HDF to use hypertonic bicarbonate substitution fluid in a smaller amount as European “biofiltration” utilized 3l with composition of Na 145 Cl 45 and HCO^-₃ 100m Eq/l.
Soft HDF were done in a similar manner as biofiltration in reduced times than control HD by 1 hour; 4hr biofiltration was compared with 5hr HD and 3hr biofiltration with 4hr HD.
Reduction rate of urea, creatinine and uric acid were significant worse in biofiltration. But pretreatment level of urea was not significant between biofiltration and HD, Suggesting increased tissue clearance. Correction of uremic acidosis was sufficient in biofiltration without excessive alkalosis despite hypertonic bicarbonate infusion. Serum level of electrolytes were not significant but increased Cl concentration in HD. Ht level was increased and trigly ceride concentration was decreased in biofiltration. All patients were well torelated in biofiltration. In conclusion, biofiltration can be applied for short time dialysis in the sense of elimination of uremic solute and correction of uremic acidosis.