1987 Volume 16 Issue 2 Pages 767-769
Sixty-one urokinase immobilized femoral vein catheters (UKFC) were applied to 56 patients as a transient blood occess. The catheters were indwelled 2 to 113 days (14 days in average) and were patent in all patients except one. Only 4 patients were suffered from catheter fever. The residual activity of UK after use was 0.1 to 6.1%, (2.1% in average). The plasma concentration of neither plasminogen nor α2-plasmin inhibitor changed very much at hemodialysis and hemorrhagic diathesis were not observed at all. Three different catheters-polyurethane femoral catheter (FC), UKFC and UKFC inactivated with (p-amidinophenyl) methanesulfonyl fluoride hydrochloride (APMSF-UKFC)-were indwelled in the jugular vein of the 4 goats 2 days and were observed with scanning electromicroscopy after pulling out. Platelets adhesion was observed on the surface of PC but not observed on the surface of both UKFC and APMSF-UKFC. We concluded that the antithrombogenicity of UKFC is owing to the inhibition of platelets adhesion to the material as well as the enhancement of fibrinolysis.
