1987 Volume 16 Issue 2 Pages 774-777
Post operative adjuvant chemotherapy of CDDP were performed in three dialysis patients with malignancy, and elimination of plasma CDDP with various blood purification methods were studied. There are two diffent components of plasma CDDP, that one is protein binding CDDP and anotheris free CDDP. Plasma platinum concentration was measured by atomic absorption spectrophotometry. Free CDDP was eliminated with HD, HDF, HE and DHP. but totalplasma platinum concentration rate reduced only 10.4-37.5%, which were not satisfactry value. However, the reduction rate of plasma total platinum consentration with PE was 68.6%, which was satisfactory effect. Steep a phase was found in the profile of plasma platinum concentration after administration of CDDP in the patient after bilateral nephrectomy. It was suggested, that the uptake of CDDP to tissue occurred rapidly. The conclusion of this study is that the most effective methods ofblood purification for reducing plasma CDDP in the dialysis patients is PE.
