Jinko Zoki
Online ISSN : 1883-6097
Print ISSN : 0300-0818
ISSN-L : 0300-0818
The limulus Amebocyte Lysate-Reactive Material derived from Cuprophane Hollow Fiber Dialyzer and Biocompatibility
K. SAKASHITAT. TSUTSUIH. KAGAMIA. ITOC. YAMAZAKIK. MASUKO
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1987 Volume 16 Issue 2 Pages 779-782

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Abstract

This study was undertaken to determine whether LAL-RM had to do with hemodialysis leukopenia and thrombocytepenia. Using the conventional CHF dialyzers and the non-LAL-RM CHF dialyzers, the leukocyte and thrombocyte inll hemodialysis patients were counted at prehemodialysis, 15 minutes, 30 minutes, 60 minutes and 240 minutes after beginning, respectively. The non-LAL-RM CHF dialyzer was made by washing with 13 liters of lactated Ringer's injection. The changes of leukocyte and thrombocyte during hemodialysis were no different between conventional CHF dialyzer and non-LAL-RM CHF one. As the control experment, two hundreds, mililiters of washing solution of AM-Neo-2000H were Injected into the nomal human (male-5, femal-3). Their leukocyte, thrombocyte and complement (CH 50) were measured at preinjection, 15 minutes, 30 minutes. 60 minutes and 120 minutes, later. There were no significant changes found in the leukocyte and complement (CH 50). It showed that the thrombocyte dicreased signifucantly at 30 minutes and 60 minutes as compared that of preinjection.

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© The Japanese Society for Artificial Organs
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