Study of biocompatibi lity with various b lood purification membranes

Abstract

To study the bio compatibility of blood purification membrane, the blood passing test was conducted by using several minimodules of different membranes at the same time on a single subject. The subjects were three healthy male and the membranes used were PE, PVA, EVAL (D) and EVAL (4A). The membrane area of each module was 0.01m². Blood was withdrawn from the median cubital vein through PVC tubings and let to five modules (one module was blank) where the blood flowed at a rate of 10ml/min. Ten minutes later, the blood was sampled to investigate the influence of each membrane material on the complement system by measuring the activation of complements (C3a, C4a). The complements were most strongly activated by PVA, followed by EVALs (D and 4A), PE, and “blank”. There was no significant difference in the effect between EVAL (D) and EVAL (4A).