1987 Volume 16 Issue 2 Pages 812-816
The biocompatibility of a new modified cellulose (MC) dialysis membrane in which 5% of cellulosic OH group are substituted by DEAE group was tested as compared to Cuprophan (Cu) and PMMA membrane. MC showed less transient leukopenia than Cu and PMMA did not. C3a generation through dialyser occured most in Cu. MC generated less C3a than Cu and PMMA was the least generator of C3a. C5a generation was only observed in Cu. β-TG slightly increased in the blood through dialyser in Cu and MC but much increased in PMMA. This was the same thing concerning PF4 too. PMN elastase, measured as PMN elastase·α1-Pi complex, increasd at same extent in these three membrane in the blood according to dialysis times, suggesting there was no relationship between PMN elastase release in the blood and the peripheral leukocyte count or serum complment considering their changes in Cu and PMMA.
