1987 Volume 16 Issue 2 Pages 865-868
In order to study the relationship among the concentrations in inlet blood (CBi), inlet dialysate (CDi), and outlet blood (CBo), the experimental hemodialyses with and without ultrafiltration were performed in vitro using creatinine, vitamin B12, and albumin as test solutes. The data obtained gave the following equation: CBo=C1·CBi+C2·CDi where C1 and C2 were constants. This equation fits well in all cases regardless of molecular weight of the solute, difference in dialyzer membrane, or the existence of ultrafiltration. On inspection of dialyzer clearance and dialysance by this equation, it was proved that they were not constants but functions of CDi/CBi and dialysance could not be used in pool models except for the case without ultrafiltration. These results suggest that this equation is a law representing the solute transport in dialyzer, and C1 and C2 are the characteristic constants representing dialyzer performance.
