Beta-2 microglobulin in various modes of hemopurification

Abstract

Removal capacities and serum concentration of beta-2 microglobulin (B-2M) were evaluated among various modes of treatments. Serum levels of B-2M could be reduced to some extent with hemodialysis (HD), hemofiltration (HF) or hemodiafiltration (HDF) using synthetic membrane filters. Reduction rate of was 60% on HF with RP-6 or HF 200 and 30% on HD with AN-69 or BK1. 0. Not only filtration and diffusion but also membrane absorption of B-2M seem to play an important role in the mechanism for B-2M removal in these synthetic membrane filter. Cuprophane dialyzer did not produce a significant change in serum B-2M. Patients on HD or CAPD had significant correlations between serum B-2M and duration of dialysis, even if patients with residual renal function were excluded for this analysis. Serum B-2M level did not change between patients with HD and CAPD, although latter removed a significant amount of B-2M and former did not. There seems to be complicated mechanisms to regulate serum levels of B-2M in various modes of treatments. Generation rate might be different between HD and CAPD, which remains to be clarified.