Abstract
Foreign body reaction works continuously during the foreign body is in the host. To observe the biological reaction against antithrombogenic materials, the polymer coated suture method (Jap. J. Artificial Organs, 11, 794, 1982) was used. Three kinds of polymers were used, i. e., heparinized hydrophilic polymer (H-RSD), hydrophilic polymer with long polyethyleneoxide side chains (PEO), and heparinized denatured keratine (HK). Macroscopically, these polymers showed excellent antithrombogenicity. No thrombus was noticed on each polymer surface, however, the mechanism and process to get antithrombogenicity were completely different from each other. In case of H-RSD, a protein layer of 1, 000A in thickness covered the polymer surface. In case of PEO, a special double membrane like cell membrane was observed in every specimen after more than 1 day. In case of HK, it could prevent from the thrombus formation during the dissolving of HK. After no more dissolving, the surface was covered with thin layer of fibrin, then was endothelialized. These three polymers can get stable antithrombogenicity in the blood stream. These results revealed that the biological reactions to antithrombogenic materials do not always work same way. The investigation of such as variant phenomena is quite improtant for the development of new antithrombogenic materials.
