Abstract
To elucidate the action of microwave(MW) for drug delivery system, the complex dielectric constants of polymers was measured in the region of 430 MHz. The results indicate that polyelectrolytes are easy to be heated by MW irradiation. Macromolecular prodrug(PHPG-MTX) was synthesized by condensation of biodegradable poly(hydroxypropyl)-L-glutamine(PHPG) with methotrexate(MTX) of anticancer drug. When irradiated with M W to this PHPG-MTX, the temperature rise of this conjugate was higher than that of base polymer, PHPG. These results suggests that this new system using MW offers a powerful method to carry out the release of anticancer toward target area only.
