SURFACE MODIFICATION OF SYNTHETIC POLYMER MATERIALS FOR MEDICAL USE

-ADDITION OF ANTIBACTERIAL AND MUCOUS SURFACE ONTO SILICONE GUM URETHRAL CATHETER

Abstract

Various synthetic polymer materials are now widely applied as biomaterials for medical use. We have investigated surface modification of such synthetic polymer materials for the purpose of making the surface bioactive. We have developed collagen-synthetic polymer composite materials, which possess high tissue-compatibility, and biofunctional materials by immobilizing enzymes and bioactive substances onto the surface of the composite materials. In this work we investigate addition of antibacterial and mucous surface onto silicone gum urethral catheters by means of graft polymerization of acrylamide and immobilization of polymyxin B onto the surface. The composite catheters have excellent antibacterial and mucous surface.