Abstract
Drug release from the matrix of segmented polyether poly (urethane-urea)(PEUU) s with soft segments of gradually varying the composition of hydrophilic poly (ethylene oxide)(PEO) and hydrophobic poly (tetramethylene oxide) was studied. Here crystal violet was used as model drug. The increase in PEO content in PEUU altered the mode of CV release from the Fickian diffusion mechanism to the zero-ordered release. However, the amount of CV release was maximized at the PEUU with appropriate PEO content. These results indicate that these PEUUs could regulate distinctive function in the mode, and amount of CV release. Therefore, it appears that these PEUUs constitute drug reservoir and transport channel to exhibit the unique feature of matrices for drug delivery formulations.
