Abstract
The influence of hypothermia during extracorporeal circulation with core cooling on enzymes and metabolic changes was studied in one hundred and six patients. The enzymes and metabolic changes were suppressed by hypothermia. The critical point of body temperature during and after extracorporeal circulation with core cooling was decided on enzymes and metabolic changes by stepwise discriminant analysis. Results were summarized as follows: 1) The critical body temperature was twenty eight centigrade and sixty minutes after initiation of perfusion and core cooling, although the lowest body temperature was brought at thirty minutes after initiation of perfusion. 2) The carbohydrate and lactic acid metabolism were significant coefficient factors of ciritical body temperature during extracorporeal circulation with core cooling. 3) The ciritical body temperature was twenty four centigrade and next morning after surgery, although, the body temperature was normal at the end of perfusion. 4) The enzyme changes were significant coefficient factors of critical body temperature after extracorporeal circulation with core cooling.
