Abstract
Extending the in vivo long-life is themost crucial point of the biosensor. For this purpose, we have coated the needle-type glucose sensor with an antithrombogenic membrane, alginate-polylysine-alginate membrane. The sensor showed highly antigenecity so as to directly measure glucose concentration in freshly sampled whole blood. The implanted sensor could monitor the tissue glucose levels as long as 14 days. Thus, the antithrombogenic membrane could augment the feasibility of the biosensor.
