Abstract
We have developed a new affinity adsorbent C-ST for a therapy of autoimxaine diseaese, C-ST has a great selectivity for irm inoglobul in Go The adsorbent consists of a chitosan bead as a matrix and sulfathiazole as a ligand, C-ST adsorbent has been applied to plasma perfusion so far.
In this study, we performed direct hemoperfusion using C-ST, modified C-ST and C-ST coated acrylic copolymer in Rabbit, Smoothly and easily practicable performance was ensured with using C-ST(07nm), Good bio-campatibiiity to blood cells was obtained by surface coating with acrylic copolymer or using spacer between matrix and ligand, And they had also efficient and selective capacity of adsorbing intnunoglobulin G.
