Abstract
When irradiated with 433-MHz microwave (MW) to the polymeric prodrug of methotrexates coupled with biodegradable poly (hydroxypropyl)-L-glutamine (PHPG), its temperature rise was higher than that of neutral PHPG. Polyelectrolytes which showed large values of the relative loss factor (ε") were easy to generate heat by 433-MHz MW irradiation. When a strong Polyelectrolyte (PE) was injected into the phantom simulated to muscle tissue in value of ε", it was confirmed that the PE was more heated than the phantom by external MW irradiation. A localized drug-admlnistration induced by selective microwave irradiation, that is, a physical targeting can be expected if the macromolecular prodrug in polyelectrolyte system is utilized.
