Abstract
The physical properties and biocompatibility of apatite-collagen composite were tested Carbonate-hydroxyapatite, CO3-Ap, which showed chemical composition and crystallinity similar to bone was synthesized (pH 7.4±0.2, 60±1°C). CO3-Ap was mixed with type I atero-collagen solution whose antigenicity was removed by enzymatic treatment and formed into apatite-collagen implants. These apatite-collagen composites exposed to UV irradiation for 4 hours reduced their solubility remarkably. These UV treated apatite-collagen composites implanted into submusclofacial part of rat abdomen showed good biocompatibility when examined histlogically.
