Abstract
The histological change of canine femoral arteries in treated with 1% glutaraldehyde (GA) was observed in vivo. After 12 months observation, the GA treated region has changed to a homogenous collagen material. In the transitional zone between the treated and untreated regions, the smooth muscle cells in the arterial wall were diminished gradually. The inner surface was almost covered with a psuedointima, which was more hyperplastic in the transitional zone and continued to the untreated normal intima smoothly. But, the collagen tube was not organized and not reconstructed by the cellular ingrowth. We concluded that GA was not suitable for the cross-linking agent to obtain an ideal collagen tube graft with favorable healing.
