Abstract
The gas transfer performances in gas-membrane-water were investigated with various membranes, and consequently optimal design of the hollow fiber membrane for artificial lungs was determined. Refer to this analysis, we developed a multilayered composite hollow fiber membrane [MHF] that has a thin dense layer. In vitro evaluation MHF showed good gas transfer for long-term perfusion, and no serum leakage was observed. Moreover, vapor loss was less enough. MHF could have the possbility for ECMO.
