Abstract
Plasma renin activity, Angiotensin I, Angiotensin II, Aldosterone, Angiotensin-converting enzyme of the blood were determined with adult mongrel dogs undergoing non-pulsatile and pulsatile extracorporeal circulation (ECC) to classify humonal and neural regulation of renin-angiotensin-aldosterone (R-A-A) system. Effects of cervical division of automatic nerves below carotid bodies were also evaluated. The blood was sampled from inferior aorta, cervical, pulmonary, renal, portal and hepatic vein to analyze activation of R-A-A system in brain, lung, kidney, portal system organs and liver. Results were as follows; 1) Activation of R-A-A system was observed in lung, kidney, and brain during ECC, and it was stronger during non-pulsatile ECC than during pulsatile ECC. 2) R-A-Asystem was dominantly influenced by division of automatic nerves at a cervical level.
