Abstract
A 78-year-old women underwent the surgery for ventricular septal perforation and then LVAD was used for 23 days. Reninangiotensin system activated in the whole postoperative period, especially for angiotensin II in 2nd, 14th and after third week. The change of noradrenaline was similar to that of angiotensin II, but adrenaline was not changed. Aldosterone increased after two weeks postoperatively. On the other hand, clinical laboratory data showed that hyperbilirubinemia appeared 2 weeks and then S-GOT, LDH, S-amylase and CK-BB elevated simultaneously 3 weeks postoperatively. On the 26th day, patient died from acute hepatic failure clinically. Autopsy revealed acute hepatic and pancreatic necrosis.
