Abstract
The effects of left ventricular, assist device (LVAD) were studied experimentally in swines with cardiogenic shock due to acute myocardial infarction (AMI). Hemodynamics, EVR, LV max dp/dt, TTI and PVR were precisely evaluated in early stage after the initiation of the LVAD. Twenty-one swines were used in this experimental study and AMI was made by means of multiple ligations of the coronary arteries. Ventricular fibrilation occurred in 11 out of 21 swines after production of AMI and mean percentage of the infarcted area of LV free wall by means of NBT staining was 63%. By application of LVAD for the profound failing heart, a significant decrease of LV max dp/dt and TTI and a marked increase of EVR were observed. Besides a diminished left ventricular preload and afterload, a decrease of the cardiac work and an increase of the coronary blood flow could be obtained. During LVAD a satisfactory systemic circulations support could be maintained in aortic pressure more than 90mmHg. However right cardiac iunction was not changed even by utilization of LVAD. The limitation of the effect of left ventricular assist by only LVAD was in about 1800 dyne sec cm-5 from the view of pulmonary vascular resistence (PVR).
