Jinko Zoki
Online ISSN : 1883-6097
Print ISSN : 0300-0818
ISSN-L : 0300-0818
EXPERIMENTAL STUDY OF A SYNTHETIC THROMBIN INHIBITOR MD805 AS ANTICOAGULANT AFTER IMPLANTATION OF LEFT VENTRICULAR ASSIST DEVICE
K. OHTAKI, K. SAKAI, T. TANABE, K. HOSOOKA, T. MATSUMOTO, Y. MITAMURA
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Keywords: Synthetic thrombin inhibitor (MD805), Anticoagulant, Left ventricular assist device, Antithrombin-III, FDP
JOURNAL FREE ACCESS

1989 Volume 18 Issue 2 Pages 592-595

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Abstract
The effect of MD805, a synthetic thrombin inhibitor as anticoagulant after implantation of left ventricular assist device was investigated. Dose of the ND805 was 20mg/day and 50mg/day. Prothrombin time and partial thromboplastin time prolonged in MD805 group more than no MD805 group. There was no difference between MD805 group and no MD805 group on the changes of platelets, fibrinogen, antithrombin-III and FDP. In MD805 group, infarct size of the kidney was decreased and there was few platelets on the blood contact surface of the pump. It is expected that MD805 reduce the dose of heparin.
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