Abstract
Fourteen adult patients undergoing open heart surgery were examined. The following parameters were determined; fibrinogen, ATIII, FPA, plasminogen, α2PI, and FPBβ15-42. In addition to these conventional parameters, TAT and α2PI-Pm complex were also measured using ELISA method. Although all patients were given heparin, progressive increase in FPA and TAT were recorded during CPB, indicating that heparinization was not able to inhibit completely the formation and function of thrombin. On the other hand, FPBβ15-42 and α2PI-Pm complex increased significantly during CPB. These findings indicate that the enhanced fibrinolytic activity, which has dissolved intravascular fibrin, is in turn rapidly inactivated by inhibitors such as α2PI.
