1989 Volume 18 Issue 3 Pages 1203-1206
In order to clarify the effects of low molecular weight heparin (LH) as an anticoagulant for hemodialysis (HD), we compared the characteristics of LH with those of ordinary heparin (OH) in patients under regular HD. Under the similar plasma anti-Xa concentration, a greater prolongation of APTT and CCT was observed in OH than that in LH. When the same anti-Xa unit of LH or OH was administered, plasma anti-Xa activity was higher in LH than that in OH. Minimum requirement dose for HD of LH was less than that of OH. A significant correlation was observed between Xa coagulation time, which was newly developed for bed side monitoring of LH activity, and plasma anti-Xa activity. HD could be performed only a bolus injection of LH without coagulation episode in extracorporeal circuit. These results incidate that LH has several preferable characteristics to OH, and LH may be useful as an anticoagulant for HD.
