EFFECT OF DESFERRIOXAMINE INFUSION ON RED BLOOD CELL ALUMINUM

Abstract

To investigate the effect of desferrioxamine (DFO) on red blood cell, serum Al(s-Al), red blood cell Al (RBC-Al) and blood hemoglobin(Hb) levels were measured periodically for 4 months after the administration of DFO for 4 months in 16 patients treated by hemodialysis (HD). The s-Al levels increased by 2 days after the administration of DFO and then decreased by day 7 to almost base line levels, but no significant changes were noticed in the RBC-Al levels until 1 month post infusion. Hb levels increased at 1 month postinfusion. Our data suggested that DFO did not seem to transfer Al into RBC or to remove the Al that had accumulated in these cells.