Jinko Zoki
Online ISSN : 1883-6097
Print ISSN : 0300-0818
ISSN-L : 0300-0818
BILIRUBIN CONJUGATION BY MULTICELLULAR SPHEROID OF ADULT RAT HEPATOCYTES IN PRIMARY CULTURE
- BASIC STUDY FOR ARTIFICAL LIVER -
M. KAWAGUCHI, N. KOIDE, K. SAKAGUCHI, K. ASANO, M. MORI, T. TSUJI
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Keywords: Hepatocyte/Monolayer, Hepatocyte/Spheroid, NPC + Hepatocyte/Spheroid, Proteoglycan, Bilirubin-Glucuronide
JOURNAL FREE ACCESS

1989 Volume 18 Issue 3 Pages 1269-1272

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Abstract
It has been reported that adult rat hepatocytes that interacted with proteoglycan in the primary culture formed Hepatocyte-Spheroid, in which the cell density was much higher than in the Hepatocyte/Monolayer. The Hepatocyte/Spheroid of adult rat hepatocytes maintained the high abilities of bilirubin glucuronide conjugation for at least 14 days. The Hepatocyte/Spheroid might be another choice of culture system for making an artifical liver.
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