Abstract
To evaluate the effectiveness of fibrin glue (FG) as a hemostatic agent in vascular surgery, an experiment by using canine model as well as and clinical studies were undertaken. In group A, the amount of bleeding from anastomotic site was compared between the group of fibrin glue sealing and the group of no treatment using PTFE graft for iliac arterial reconstruction. In group B, Golaski vascular graft was pretreated with fibrin glue in experimental group and also the amount of hemorrhage from vascular graft in certain length was compared to that of non treated group. The amount of bleeding was significantly lower in fibrin glue pretreatment group than that of control one. In clinical application, the same design of study was undertaken with the patient who had aorto-iliac reconstructive surgery for aneurysmal or occlusive disease by using knitted dacron bifurcation graft. It was also found that bleeding was well controled in fibrin glue treated vascular graft. The microscopic examination of graft-arterial specimens at the anastomotic site harvested 1 month after implantation revealed the presence of no significant inflammatory reaction. We concluded that fibrin glue provides good hemostatic action in the practice of vascular surgery.
