EXPERIMENTAL STUDY ABOUT THE PROSPECTIVE CONTROL OF THE VENTRICULAR ASSIST DEVICE USING MULTIPLE REGRESSION ANALYSIS OF THE SYMPATHETIC TONE AND HEMODYNAMIC DATA

Abstract

In order to develop the real time automatic control system of the ventricular assist device, we use the multiple regression analysis of the sympathetic tone and hemodynamic data. Mean left atrial pressure and mean aortic pressure were used as the parameters of the preload and afterload, and Renal Sympathetic Nerve Activity was also utilized to evaluate the sympathetic tone. A functional formula of the prospective cardiac output was calculated by the time series data of the acute animal experiments using adult mongrel dogs. A significant correlation was observed between the prospective cardiac output and the measured cardiac output.This result suggests the possibility of the prospective control of the artificial heart.