Abstract
Thrombus formation is one of the most difficult problems in total artificial heart experiment. Hypercoagulability showing a marked decrease in platelet count and antithrombin III level, and increase in fibrinopeptide A and Bβ15-42 levels, relates closely to thrombus formation. Hypercoagulability develops not only during and immediate after surgery, but also during postoperative complication such as sepsis. We concluded the necessity of anticoagulation therapy during a hypercoagulable state after total artificial heart replacement.