EFFECT OF APROTININ ON COAGULOFIBRINOLYTIC SYATEM AND PLATELET FINCTION DURING EXTRACOPPOREAL CIRCULATION

Abstract

This study, included 20 patients undergoing cardiac surgery with extracorporeal circuration (ECC), was performed to investigate the effect of Aprotinin (AP) on hemostatic mechanisms during ECC. Eleven of these patients were control group. AP group included other 9 patients who had administrated AP (1500KIU/kg) at start of ECC. In both group, TAT and α₂ PI-PmC were increased immediateiy after the start of ECC. TAT was less in AP group than in control group, and the fibrinolytic parameters indicated the prevention of fibrinolytic activity by AP. Perioperative blood loss were significatnly less in AP group than in control group. But there was no significant differnce in platelet activity between both groups.