Abstract
We compared the dialysance by protein permeable meubrane (PPM) with that of ordinary membrane (NPM) by measuring drug clearance rate(Cl) In four chronic hemodialysis patients. After administering five kinds of drugs with different protein binding rates (PB); digoxin, famotidine, CZX, CFX and CMZ, the Cl of each drug was measured using BK-1.6, DUO-FLUX and EL201-12C as PPM and TFU-15M as NPM. Almost the same Cl were obteined for the lower PB drugs regardless of their molecular weights. For the higher PB drugs, to Cl were reduced, but the reductions were smaller in PPM. It is considered that the dialysance of the lower PB drugs by PPM is similar to that by NPM because they are removed mainly by diffusion, on the other hand, the dialysance of the higher PB drugs by PPM is superlor to that by NPM because of its protein permeability.
