Abstract
Evaluation of β2-microgiobulin removal by cuprammonium rayon membrane applied with enlargement of pore size. In vitro experiments were conducted by use of a cuprammonium rayon membrane (UP membrane) improved in the reduction rate of β2-MG and EP membrane applied with enlargement of pore size, and permeation performances of substances primarily of β2-MG were investigated.
Sieving coefficients of β2-MG, albumin in bovine serum system were 0.45, 0.01 or less for UP membrane, and 0.65, 0.01 or less for EP membrane, respectively. Mass transfer coefficients of β2-MG, urea were 0.21×10-4, 12.6×10-4cm/sec for UP membrane and 0.45×10-4, 11.6×10-4cm/sec for EP membrane, respectively.
From these results, it has been found that the EP membrane has sharp molecular weight cut-off characteristic, and little albumin is leaked out.
EP membrane can be expected to reduce larger amount of β2-MG by the HD method than UP membrane.
