Abstract
In an attemp t to clarify how effectively an intermittent or a continuous hemopurificat ion can reduced the plasma β2-microg lobulin (β2-MG) level we made kinetic models for the indivisual treatment, respectively, and estimated the changes in the plasma concentration following the treatment switch from a conventional HD too an HD or HDF with a β2-MG permiable high performance membrane or continuous ones such as CAPD. The results indicated that in the case of an intermittent hemopurification steady decrease of the plasma concentration would not be obtained because of the rebound phenomenon between treatments. This tendancy is particularly conspicuous in patients whose initial plasma β2-MG level is relatively lower among ESRD patients (eg.30mg/L) The results also indicated that in the case of a continuous one a steady decrease could be obtained however, CAPD would not offer this because of the extremely low peritoneal membrane clearance.
