Abstract
Plasma exchage (PE) for liver failure following the abdominal operation was evaluated retrospectively using bilirubin fractionation. Delta bilirubin (Bδ) is the albumin-bound fraction determined using high performance liquid chromatography and shows characteristic changes in hepatobiliary diseases with changes in monoconjugated bilirubin (MCB). PE using fresh frozen plasma (FFP) was successful in two of nine cases. Our analysis revealed not only differences in the ratios of MCB/Bδ and Bδ/(MCB+DCB+Bδ) in pretreatment sera but differences in pre to post changes during PE, suggesting that the improved case had a different quality hyperbilirubinemia and a diffrent disease entity before PE, as well as a different response to PE.
