Abstract
Catheter-related sepsis (CRS) is a major complication of long-term parenteral nutrition. To prevent a CRS, especially to block a microbial entering from catheter insertion point, we developed a intravenous catheter with percutaneous device made of dense sintered hydroxyapatite(HAp-PD). We tried it 32 times for 28 patients. Catheterization period ranged from 5 to 211 days, and mean catheterization period (76.ldays) is longer than that of conventional catheter (20.8 days)(P<0.01). Catheter sepsis frequency index (CSFI, CRS/1000 catheterization days) is 1.23, also lower than that of conventional catheter(5.69)(P<0.01). HAp-PD fitted to skin tightly without disinfecting treatment, and patients enjoyed taking a bath. This trial proved a clinical usefullness of a catheter with HAp-PD.
