Abstract
Platelet Activating Factor (PAF) is an important factor in the activation of platelet and leucocyte. It is known that complement, platlet and leucocyte are activated in cardiopulmonary bypass (CPB). We measured the change of PAF level in 10 adult patients who underwent CPB. PAF level increased in the first 5 minutes from 527±69.0pg/ml to 776.1±111.2pg/ml, and then decreased slightly. After 5 minutes of aortic declamping, PAF level was 515.6±68.2pg/ml. Platelet counts, β-TG, PF4, and 11-dehydroTxB2 suggested that platelet was rapidly activated in the first 5 minutes of CPB. These data suggest that platelet may be activated immediately after starting the CPB, and PAP may play an important role in platelet activation during CPB. Interestingly the potency of PAF for platelet activation was stronger at 25°C than 37°C. Therefore, it may also be important to prevent the PAF action during hypothermic CPB.
