Abstract
The ability of polyacrylnytril hollowfiber hemoconcentrators (ASA800) to prevent loss of plasma protein was evaluated clinically in 30 patients during open-heart surgery. ASA800 were used in 16 patients for 92.6±40.7 minutes and were able to remove 1885.5±914.lmIl of water from diluted blood during CPB. Total serum pro-tein concentration during CPB decreased temporarily to 3.4mg/dl(Ht 16.5%) but stabilized at more than 4.5mg/dl(Ht20%). There was no significant difference in blood components after CPB between the group with ASA800 and that without ASA800. After the CPB, hemoconcentration of the residual priming blood was performed with ASA800. A slight elevation of linepressure and a prolongation of time required for hemoconcentration was found to occur as a result of plugging of the hollowfiber pores by plasma plotein. ASA800 was effective in hemoconcentratiog the priming blood of CPB both in terms of concentration of blood components and hemoconcentration rate. We concluded that ASA800 was useful for concentrating the hemodiluted priming blood both during and after CPB.
