EXPERIMENTAL EVALUATION OF ABIOMED BI-VENTRICULAR SUPPORT SYSTEM 5000 WITH AN ARTIFICIAL ATRIUM AND POLYURETHANE TRILEAFLET VALVE

Abstract

ABIOMED Bi-Ventricular Support (BVS) System 5000 was evaluated in mock circulation and acute animal experiments. The device consists of a disposable blood pump and electromechanical console. The blood pump is driven pneumatically without vacuum (with gravity-filled) and has an inflow chamber (artificial atrium: 100ml volume), an outflow chamber (pumping chamber: 100ml volume) and two polyurethane trileaf let valves. The priming volume of this system is 550ml. The console can operate two pumps independently and asynchronously with fill to empty mode. In mock circulation, maximum pump flow was 5.3L/min with ABIOMED console and was 5.8L/min with TOYOBO VCT30 console. In left heart failure model using mock circulation, BVS system 5000 showed ability to maintain circulation when the preload exceeds 10mmHg. In acute animal experiment using 57kg goat, maximum pump flow of left ventricular assist was 4.3L/min. In bi-ventricular assist using 60kg goat, maximum left pump flow was 5.0L/min and maximum right pump flow was 4.8L/min. ABIOMED BVS System 5000 has enough ability of circulatory support, however, the priming volume is large for Japanese. It is necessary for Japanese to modify the pump or cannula size.