Abstract
Effect of Urinastatin during Right Ventricular Assist Ventricular assist device(VAD) has become utilized widely for clinical application. Multiple organ failure (MOF) which occurs while VAD is using is in a high mortality, and it is essential to pursue the cause and be prepared with countermeasures. In the present study, we examined the histological change of the pulmonary tissues, measuring of granulocyte elastase activity and extravascular lung water ( EVLW) when RVAD were used in 16 pigs. Urinastatin, protease inhibiter, stabilizes the lysosomal membrane. It was administered to 8 animal during RVAD . After right ventricular failure, RVAD was started. RVAD was operated for 3 hours. The result might be well explained that hemodynamic conditions were well stabilized in RVAD. But it was suggested from measuring of granulocyte elastase that the ischemic changes at the cellular level were still being advanced, and administration of urinastatin can prevent the cellular destruction during R VAD, it is considered that RVAD may induce pulmonary dysfuntion due to advanced permeability in the system of pulmonary capillary vessel and edema in the inter-alveolar septum. It was suggested from the histologi-cal change of lung tissues and EVLW that the edema can be inhibited by urinastatin.
