Abstract
The interrelationships between hemodynamic variables including right ventricular (RV) performance and filling/ejection dynamics of Novacor LVAD were investigated in 10 patients who received the LVAD as a bridge to heart transplant. Data were obtained intraoperatively, at periodic intervals, up to 48 hours post implant and at explant. During the period of LVAD support, pumping characteristics showed filling volume of 24-70ml, residual volume of 1-18ml, pump rate of 63-175/minute and pump output of 2.8-8.2 l/minute. Multiple regression analysis identified PVR, RVSWI and PCWP as the significant (p<0.001, R2=0.6) parameters affecting LVAD filling volume. LVAD pump output was influenced mainly by RVSWI, PVR and SVR. (p<0.001, R2=0.7) These results indicate that Novacor LVAD performance is highly dependent upon RV function and systemic/pulmonary vascular resistances.
